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However, it is estimated that up to 25% of type 2 diabetic patients suffer paraesthesia, described as a prickling and tingling sensation, hyperesthesia or overt pain described as burning, sharp, electric shock-like and lancinating.2 Untreated pain often leads to significant disability, such as reduced physical activity, poor sleep quality, and worsening anxiety and depression.3 These complications can lead to significant financial burdens on patients and the healthcare system

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In a 9-month monkey oral toxicity study, all female monkeys in the high-dose group showed minimal-to-slight periportal hepatocyte vacuolation

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